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国际皮肤性病学杂志(英文)【2020年第04期】

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International Journal of Dermatology and Vernereology(简称IJDV)于2018年创刊,是目前大陆地区第一本也是唯一的英文皮肤性病学期刊。IJDV旨在为皮肤性病学及相关领域的临床医生和研究人员提供一个国际性开放平台,促进本学科各个方向包括流行病、病因、诊断和治疗的全面交流。过去的几十年,国内皮肤性病学包括遗传学,流行病学等发展迅速,科研成果倍出,有国际学术交流的迫切需要,但令人遗憾的是,大陆地区没有一本自主产权的皮肤病学英文刊可以提供这样的平台。因此,中华医学会和中国医学科学院皮肤病医院(皮肤病研究所)联手将原来的中文刊《国际皮肤性病学杂志》改刊为全英文的IJDV。中华医学会是国内最大的医学组织,具有丰富的办刊经验和资源。皮肤病研究所是全国皮肤病和性病学专业机构,也是国家性病和麻风控制中心和WHO性传播疾病预防和控制合作中心。研究所具有国内皮肤病学最全面的亚学科,是国内皮肤性学学术和科研力量最强的研究机构之一。编辑部有丰富的办刊经验,出版《中华皮肤科杂志》在皮肤性病学影响因子排名第一。目前IJDV已经有了超过2万人的微信粉丝群并在持续增加,为其影响力的快速提升打下了良好的基础。IJDV正在和荷兰威科商谈合作出版,力争在3-5年内实现期刊的国际化。

Efficacy and Safety of Prednisolone Monotherapy Versus Prednisolone Plus Methotrexate in Erythema Nodosum Leprosum (Type 2 Lepra Reaction)

2021-01-10 19:13:19 医药卫生 Hasan 
资料简介

AbstractObjective:This study was performed to compare the efficacy and safety of methotrexate (MTX) plus prednisolone versus prednisolone monotherapy in patients with erythema nodosum leprosum (ENL).Methods:This comparative clinical study was performed in the Chittagong Medical College Hospital, Bangladesh from June 2018 to December 2019. Nineteen patients were selected according to inclusion criteria and randomly allocated to either the MTX plus prednisolone group (Group A, n= 10) or the prednisolone monotherapy group (Group B, n = 9). All patients were followed up until the end of the 6-month duration of therapy to observe the clinical outcomes and adverse effects.Results:All patients in both groups showed significant improvement (P= 0.005 and P= 0.008 in Group A and B, respectively). However, prednisolone-related adverse events were more frequent in Group B.Conclusion:The present study has demonstrated that a combination of prednisolone and MTX is a safer and more effective treatment than steroid monotherapy in ENL patients including the healing of nodules. However, this combination therapy did not appear to have a significant steroid-sparing effect, possibly because of the small sample size and short study period. Therefore, a well-designed multicenter randomized controlled trial is recommended for validation of MTX with prednisolone for the management of ENL.

AbstractObjective:This study was performed to compare the efficacy and safety of methotrexate (MTX) plus prednisolone versus prednisolone monotherapy in patients with erythema nodosum leprosum (ENL).Methods:This comparative clinical study was performed in the Chittagong Medical College Hospital, Bangladesh from June 2018 to December 2019. Nineteen patients were selected according to inclusion criteria and randomly allocated to either the MTX plus prednisolone group (Group A, n= 10) or the prednisolone monotherapy group (Group B, n = 9). All patients were followed up until the end of the 6-month duration of therapy to observe the clinical outcomes and adverse effects.Results:All patients in both groups showed significant improvement (P= 0.005 and P= 0.008 in Group A and B, respectively). However, prednisolone-related adverse events were more frequent in Group B.Conclusion:The present study has demonstrated that a combination of prednisolone and MTX is a safer and more effective treatment than steroid monotherapy in ENL patients including the healing of nodules. However, this combination therapy did not appear to have a significant steroid-sparing effect, possibly because of the small sample size and short study period. Therefore, a well-designed multicenter randomized controlled trial is recommended for validation of MTX with prednisolone for the management of ENL.