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国际皮肤性病学杂志(英文)【2020年第04期】

内容简介
International Journal of Dermatology and Vernereology(简称IJDV)于2018年创刊,是目前大陆地区第一本也是唯一的英文皮肤性病学期刊。IJDV旨在为皮肤性病学及相关领域的临床医生和研究人员提供一个国际性开放平台,促进本学科各个方向包括流行病、病因、诊断和治疗的全面交流。过去的几十年,国内皮肤性病学包括遗传学,流行病学等发展迅速,科研成果倍出,有国际学术交流的迫切需要,但令人遗憾的是,大陆地区没有一本自主产权的皮肤病学英文刊可以提供这样的平台。因此,中华医学会和中国医学科学院皮肤病医院(皮肤病研究所)联手将原来的中文刊《国际皮肤性病学杂志》改刊为全英文的IJDV。中华医学会是国内最大的医学组织,具有丰富的办刊经验和资源。皮肤病研究所是全国皮肤病和性病学专业机构,也是国家性病和麻风控制中心和WHO性传播疾病预防和控制合作中心。研究所具有国内皮肤病学最全面的亚学科,是国内皮肤性学学术和科研力量最强的研究机构之一。编辑部有丰富的办刊经验,出版《中华皮肤科杂志》在皮肤性病学影响因子排名第一。目前IJDV已经有了超过2万人的微信粉丝群并在持续增加,为其影响力的快速提升打下了良好的基础。IJDV正在和荷兰威科商谈合作出版,力争在3-5年内实现期刊的国际化。

Complete Draft Genome Sequence of Cutibacterium (Propionibacterium) acnes Type Strain ATCC6919

2021-01-10 19:13:19 医药卫生 Tang 
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AbstractObjectives:The wide use of antibiotics for acne is the main cause of drug-resistant Cutibacterium acnes. However, the complete genetic sequence reference of C. acnes has not yet been reported. Herein, we report the complete genetic sequence of Cutibacterium acnes type strain ATCC6919.Methods:Whole-genome sequencing of Cutibacterium acnes ATCC6919 was performed using both the Illumina Hiseq4000 and PacBio RSII single-molecule real-time sequencing platforms. The generated sequence reads were de novo assembled using the HGAP3 protocol of single-molecule real-time analysis v.2.3.0 software. The draft genome was annotated and further analyzed by various bioinformatics tools.Results:The total genome length of Cutibacterium acnes ATCC6919 was 2,495,001 bp (60.02% G + C content), with 2,450 coding sequences including 2,358 proteins, 45 tRNAs, 9 rRNAs, and 1 sRNA. The Comprehensive Antibiotic Resistance Database showed that the gene (thy A) found in ATCC6919 was associated with resistance to aminosalicylic acid. Antimicrobial susceptibility testing showed that this isolate was not sensitive to metronidazole and sulfamethoxazole, but was sensitive to all other tested antimicrobials (erythromycin, azithromycin, clarithromycin, tetracycline, minocycline, trimethoprim, levofloxacin, ceftriaxone, and doxycycline).Conclusion:This study reports the complete genome sequence of Cutibacterium acnes ATCC6919, which provides a valuable reference for comparative analysis based on the genomic characteristics and resistance gene diversity of Cutibacterium acnes.

AbstractObjectives:The wide use of antibiotics for acne is the main cause of drug-resistant Cutibacterium acnes. However, the complete genetic sequence reference of C. acnes has not yet been reported. Herein, we report the complete genetic sequence of Cutibacterium acnes type strain ATCC6919.Methods:Whole-genome sequencing of Cutibacterium acnes ATCC6919 was performed using both the Illumina Hiseq4000 and PacBio RSII single-molecule real-time sequencing platforms. The generated sequence reads were de novo assembled using the HGAP3 protocol of single-molecule real-time analysis v.2.3.0 software. The draft genome was annotated and further analyzed by various bioinformatics tools.Results:The total genome length of Cutibacterium acnes ATCC6919 was 2,495,001 bp (60.02% G + C content), with 2,450 coding sequences including 2,358 proteins, 45 tRNAs, 9 rRNAs, and 1 sRNA. The Comprehensive Antibiotic Resistance Database showed that the gene (thy A) found in ATCC6919 was associated with resistance to aminosalicylic acid. Antimicrobial susceptibility testing showed that this isolate was not sensitive to metronidazole and sulfamethoxazole, but was sensitive to all other tested antimicrobials (erythromycin, azithromycin, clarithromycin, tetracycline, minocycline, trimethoprim, levofloxacin, ceftriaxone, and doxycycline).Conclusion:This study reports the complete genome sequence of Cutibacterium acnes ATCC6919, which provides a valuable reference for comparative analysis based on the genomic characteristics and resistance gene diversity of Cutibacterium acnes.