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国际皮肤性病学杂志(英文)【2020年第04期】

内容简介
International Journal of Dermatology and Vernereology(简称IJDV)于2018年创刊,是目前大陆地区第一本也是唯一的英文皮肤性病学期刊。IJDV旨在为皮肤性病学及相关领域的临床医生和研究人员提供一个国际性开放平台,促进本学科各个方向包括流行病、病因、诊断和治疗的全面交流。过去的几十年,国内皮肤性病学包括遗传学,流行病学等发展迅速,科研成果倍出,有国际学术交流的迫切需要,但令人遗憾的是,大陆地区没有一本自主产权的皮肤病学英文刊可以提供这样的平台。因此,中华医学会和中国医学科学院皮肤病医院(皮肤病研究所)联手将原来的中文刊《国际皮肤性病学杂志》改刊为全英文的IJDV。中华医学会是国内最大的医学组织,具有丰富的办刊经验和资源。皮肤病研究所是全国皮肤病和性病学专业机构,也是国家性病和麻风控制中心和WHO性传播疾病预防和控制合作中心。研究所具有国内皮肤病学最全面的亚学科,是国内皮肤性学学术和科研力量最强的研究机构之一。编辑部有丰富的办刊经验,出版《中华皮肤科杂志》在皮肤性病学影响因子排名第一。目前IJDV已经有了超过2万人的微信粉丝群并在持续增加,为其影响力的快速提升打下了良好的基础。IJDV正在和荷兰威科商谈合作出版,力争在3-5年内实现期刊的国际化。

The Immune Function of Keratinocytes in Anti-Pathogen Infection in the Skin

2021-01-10 19:13:19 医药卫生 Wang 
资料简介

AbstractKeratinocytes, located in the outer part of human skin, are the main epidermal cell type and play an essential role in skins defense against infection. Besides creating a physical barrier between the environment and the internal body, keratinocytes exert powerful immune function in anti-pathogen infection in the skin. At the recognition stage, pattern recognition receptors (PRRs) expressed by keratinocytes sense pathogen-associated molecular patterns (PAMPs) existing in pathogens. Toll like receptors (TLRs) are the most important PRRs in keratinocytes. Other PRRs such as dectin-1 and nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are also found to participate in this process. Activated PRRs enhance the secretion of cytokines, chemokines and the production of antimicrobial peptides (AMPs). Proinflammatory cytokines tumor necrosis factor-α, interleukin (IL)-1α, IL-6, IL-1β and IL-18, chemokines (C-X-Cmotif) ligand (CXCL) 1, CXCL2, CCL20, CCL2 and IL-8, AMPs human β-defensin (HBD) 2, HBD3 and LL37 are the main molecules expressed in this procedure. Thymic stromal lymphopoietin (TSLP), IL-36γ, IL-17 family member IL- 17C and anti-inflammatory cytokine IL-10 can also be secreted. Some molecules produced by keratinocytes such as ribonuclease 5 and 7, S100 proteins own antimicrobial properties. Keratinocytes defense responses can be regulated by internal and external factors. This review summarizes recent advances on the innate immune function of keratinocytes against infection, promoting the finding of a new direction for avoiding severe skin infection as well as the potential treatment of keratinocyte-associated inflammatory dermatosis.

AbstractKeratinocytes, located in the outer part of human skin, are the main epidermal cell type and play an essential role in skins defense against infection. Besides creating a physical barrier between the environment and the internal body, keratinocytes exert powerful immune function in anti-pathogen infection in the skin. At the recognition stage, pattern recognition receptors (PRRs) expressed by keratinocytes sense pathogen-associated molecular patterns (PAMPs) existing in pathogens. Toll like receptors (TLRs) are the most important PRRs in keratinocytes. Other PRRs such as dectin-1 and nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are also found to participate in this process. Activated PRRs enhance the secretion of cytokines, chemokines and the production of antimicrobial peptides (AMPs). Proinflammatory cytokines tumor necrosis factor-α, interleukin (IL)-1α, IL-6, IL-1β and IL-18, chemokines (C-X-Cmotif) ligand (CXCL) 1, CXCL2, CCL20, CCL2 and IL-8, AMPs human β-defensin (HBD) 2, HBD3 and LL37 are the main molecules expressed in this procedure. Thymic stromal lymphopoietin (TSLP), IL-36γ, IL-17 family member IL- 17C and anti-inflammatory cytokine IL-10 can also be secreted. Some molecules produced by keratinocytes such as ribonuclease 5 and 7, S100 proteins own antimicrobial properties. Keratinocytes defense responses can be regulated by internal and external factors. This review summarizes recent advances on the innate immune function of keratinocytes against infection, promoting the finding of a new direction for avoiding severe skin infection as well as the potential treatment of keratinocyte-associated inflammatory dermatosis.